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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Rhein, Doxorubicin
Phytochemical Name Rhein (PubChem CID: 10168 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 299
Ref_1
Pair Name Rhein, Doxorubicin
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Gene Regulation Up-regulation Activity CASP3 hsa836
In Vitro Model SMMC-7721 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0534
Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
Result Our data indicate that a decline in mitochondrial energy metabolism was responsible for the synergistic antitumor effects of rhein and DOX in hepatocellular carcinoma cells. Reduction of ΔΨm and opening of mPTP inhibited the exchange of ATP/adenosine diphosphate between mitochondrial matrix and cytoplasm is the important mechanism.
03. Reference
No. Title Href
1 Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells. J Cell Biochem. 2020 Oct;121(10):4009-4021. doi: 10.1002/jcb.27514. Click
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